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Santi began modeling at the age of 14. She started working as an adult model under the name Natalia Cruz, becoming the Penthouse Pet of the month for November 2002 and Penthouse Pet of the Year runner-up for 2005.
Later in 2005, she signed an exclusive contract with the porn studio Digital Playground At that time, she also changed her stage name to Sophia Santi and trademarked it, stating that she did not own the website NataliaCruz.com and she "didn't want the person that owned that site to capitalize on all the marketing that (Digital Playground is) doing for me".To date, her most notable adult film appearance has been in Island Fever 4. At the age of 18, Santi began a very large tattoo of a Japanese dragon, which covers most of her back and her left side.
Santi is interested in both natural medicine and spirituality. She is a devotee of Ayurvedic and Tantric philosophies.