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With her slim figure and large breasts she quickly became a popular AV performer, appearing in at least 40 adult videos within two years of her debut. She ceased AV appearances for five years beginning in 1991. During this time she worked as a nude model while travelling between the United States and Japan. Her AV career resumed in 1996 and concluded with her retirement in 2002.
A woman of many talents, during her AV and acting career Saejima also worked as a writer, a rock group vocalist, and a beauty counselor. After her retirement from public appearances in 2002 it was reported that she was working as an artist. In a sign of Saejima's international popularity, the Taiwan rock band, Goodbye!Nao! was named in tribute to her.