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She was married to a DJ named Franck, but debts prompted her to work in the porn industry. She and her husband started doing scenes as a couple. In the 1997 film L'IndÃ©cente aux enfer she also started to have scenes with other partners. Once they had divorced, her ex-husband quit but Karen remained in the industry and continued to appear in pornographic films both in Europe and the United States.
Lancaume engaged in group sex, anal sex and double penetration in her films, as in World Sex Tour 21, for example. However, she always refused to appear in BDSM and/or gangbang scenes.
She is best known internationally as Nadine in the 2000 film Baise-moi.