Her boss spotted this and told Romain that she could be in the magazine if she wanted. After he made some contacts, she began working in the adult film business. After her discovery by the Floyd Agency, an adult film agency, back in 2001, she worked in the European adult industry until August 2005 when she moved to the United States. She has been represented by Mark Spiegler of Spiegler Girls, Derek Hay of LA Direct Models, and Swedish porn director Mikael Grundström.

She has the reputation of being a "double anal queen"; an industry term used to describe a performer who is particularly adept at multiple simultaneous anal penetration. Sandra has performed double anal and triple anal.

Sandra is great friends with fellow porn actress, Melissa Lauren. On the evening of 13 January 2007 she won four awards at the 24th AVN Awards in Las Vegas. Sandra Romain moved back to Romania in early 2008 to start a family with her husband and her dream is to start a hotel back in Romania